VDR is a gene that encodes for a protein that acts as a receptor vitamin D which regulates bone growth and calcium absorption. A variant of the gene (rs2228570 FokI polymorphism) is associated with reduced bone mineral density among prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and the temporal on-and-off occupancy of the VDRE between the two components. It is also influenced by chromosomal position and binding preferences for specific hormones. Microarray studies of human cells demonstrate that more than 100 genes have a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the try this web-site recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository of data and documents relevant to legal transactions, business or proceedings that are restricted in viewing printing, downloading, or viewing. It uses central servers and an extranet connection that is an Internet connection with restricted access, to offer controlled login times when users can view the data and documents.
Companies that deal with investment bankers and in mergers and acquisitions are the most frequent users of VDRs. VDR. They need a secure platform for sharing information with potential buyers or investors in a manner that is transparent and due diligence may require large amounts of information. Life science companies also utilize VDRs for everything from clinical trials results to HIPAA compliance documents.
